| First Author | Marine JC | Year | 1999 |
| Journal | Cell | Volume | 98 |
| Issue | 5 | Pages | 609-16 |
| PubMed ID | 10490100 | Mgi Jnum | J:57475 |
| Mgi Id | MGI:1344849 | Doi | 10.1016/s0092-8674(00)80048-3 |
| Citation | Marine JC, et al. (1999) SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98(5):609-16 |
| abstractText | SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single positive cells. Peripheral T cells express activation antigens and proliferate to IL-2 in the absence of anti-CD3. In addition, IFNgamma is present in the serum. Reconstitution of the lymphoid lineage of JAK3-deficient mice with SOCS1-deficient stem cells recapitulates the lethality and T cell alterations. Introducing a RAG2 or IFNgamma deficiency eliminates lethality. The results demonstrate that lymphocytes are critical to SOCS1-associated perinatal lethality and implicate SOCS1 in lymphocyte differentiation or regulation. |
