| First Author | Delconte RB | Year | 2016 |
| Journal | Immunity | Volume | 44 |
| Issue | 1 | Pages | 103-115 |
| PubMed ID | 26795246 | Mgi Jnum | J:263563 |
| Mgi Id | MGI:6141518 | Doi | 10.1016/j.immuni.2015.12.007 |
| Citation | Delconte RB, et al. (2016) The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15. Immunity 44(1):103-115 |
| abstractText | The inhibitor of DNA binding 2 (Id2) is essential for natural killer (NK) cell development with its canonical role being to antagonize E-protein function and alternate lineage fate. Here we have identified a key role for Id2 in regulating interleukin-15 (IL-15) receptor signaling and homeostasis of NK cells by repressing multiple E-protein target genes including Socs3. Id2 deletion in mature NK cells was incompatible with their homeostasis due to impaired IL-15 receptor signaling and metabolic function and this could be rescued by strong IL-15 receptor stimulation or genetic ablation of Socs3. During NK cell maturation, we observed an inverse correlation between E-protein target genes and Id2. These results shift the current paradigm on the role of ID2, indicating that it is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15. |
