| First Author | Caretto D | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 1 | Pages | 30-4 |
| PubMed ID | 19949064 | Mgi Jnum | J:159046 |
| Mgi Id | MGI:4441105 | Doi | 10.4049/jimmunol.0903412 |
| Citation | Caretto D, et al. (2010) Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol 184(1):30-4 |
| abstractText | The possibility that effector T cells can be converted into forkhead box P3(+) regulatory T cells (Tregs) has potential therapeutic implications. To analyze the relationship between Th1 effectors and Tregs, we have used a model of systemic autoimmunity in which both effector and Tregs arise from a single population specific for a transgene-encoded systemic protein. In vitro, the presence of IFN-gamma inhibits Treg generation during activation. Using IFN-gamma reporter mice, we demonstrate that IFN-gamma-producing cells tend not to develop into Tregs, and Th1 priming of T cells prior to cell transfer limits the number of forkhead box P3(+) T cells generated in vivo. Moreover, transfer of IFN-gamma(-/-) or STAT1(-/-) T cells resulted in an increase in the number of Tregs. These data support a role for Th1 effector molecules and transcription factors in the control of peripheral Treg generation and demonstrates the limited plasticity of Th1 populations. |
