| First Author | Drewry LL | Year | 2023 |
| Journal | J Immunol | Volume | 210 |
| Issue | 9 | Pages | 1305-1313 |
| PubMed ID | 36939394 | Mgi Jnum | J:353351 |
| Mgi Id | MGI:7471358 | Doi | 10.4049/jimmunol.2200899 |
| Citation | Drewry LL, et al. (2023) CD4 T Cell-Dependent and -Independent Roles for IFN-gamma in Blood-Stage Malaria. J Immunol 210(9):1305-1313 |
| abstractText | Production of IFN-gamma by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protection against malarial disease remain largely untested in vivo. Here we used a CD4 T cell-restricted Cre-Lox IFN-gamma excision mouse model to test whether and how CD4 T cell-derived IFN-gamma controls blood-stage malaria. Although complete absence of IFN-gamma compromised control of the acute and the chronic, recrudescent blood-stage infections with P. c. chabaudi, we identified a specific, albeit modest, role for CD4 T cell-derived IFN-gamma in limiting parasite burden only during the chronic stages of P. c. chabaudi malaria. CD4 T cell IFN-gamma promoted IgG Ab class switching to the IgG2c isotype during P. c. chabaudi malaria in C57BL/6 mice. Unexpectedly, our data do not support gross defects in phagocytic activity in IFN-gamma-deficient hosts infected with blood-stage malaria. Together, our data confirm CD4 T cell-dependent roles for IFN-gamma but suggest CD4 T cell-independent roles for IFN-gamma in immune responses to blood-stage malaria. |
