| First Author | Shi FD | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 3 | Pages | 245-51 |
| PubMed ID | 10973283 | Mgi Jnum | J:64350 |
| Mgi Id | MGI:1889127 | Doi | 10.1038/79792 |
| Citation | Shi FD, et al. (2000) Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol 1(3):245-51 |
| abstractText | Natural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+T cells, were found to participate in the development of myasthenia gravis (a T cell-dependent, B cell- and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type I helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells. |
