| First Author | Kobayashi T | Year | 2012 |
| Journal | Immunology | Volume | 136 |
| Issue | 1 | Pages | 86-95 |
| PubMed ID | 22268994 | Mgi Jnum | J:184091 |
| Mgi Id | MGI:5320245 | Doi | 10.1111/j.1365-2567.2012.03562.x |
| Citation | Kobayashi T, et al. (2012) Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-gamma and interleukin-10. Immunology 136(1):86-95 |
| abstractText | Wild-type (WT) and CD1d(-/-) [without natural killer (NK) T cells] mice were treated with zymosan A to induce granuloma formation in the liver. Increased granuloma formation was seen in NKT-less mice on days 7 and 14 after administration. WT mice showed limited granuloma formation, and zymosan A eventually induced NKT cell accumulation as identified by their surface marker (e.g. CD1d-tetramer). Zymosan A augmented the expression of Toll-like receptor 2 on the cell surface of both macrophages and NKT cells. One possible reason for accelerated granuloma formation in NKT-less mice was increased production of interferon- gamma (IFN-gamma); a theory that was confirmed using IFN-gamma(-/-) mice. Also, zymosan A increased interleukin-10 production in WT mice, which suppresses IFN-gamma production. Taken together, these results suggest that NKT cells in the liver have the potential to suppress zymosan A-mediated granuloma formation. |
