| First Author | Rana VS | Year | 2023 |
| Journal | Science | Volume | 379 |
| Issue | 6628 | Pages | eabl3837 |
| PubMed ID | 36634189 | Mgi Jnum | J:337146 |
| Mgi Id | MGI:7428840 | Doi | 10.1126/science.abl3837 |
| Citation | Rana VS, et al. (2023) Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development. Science 379(6628):eabl3837 |
| abstractText | Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-gamma). Host-derived IFN-gamma facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development. |
