| First Author | Fujigaki S | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 8 | Pages | 2313-8 |
| PubMed ID | 11477543 | Mgi Jnum | J:71158 |
| Mgi Id | MGI:2149247 | Doi | 10.1002/1521-4141(200108)31:8<2313::aid-immu2313>3.0.co;2-s |
| Citation | Fujigaki S, et al. (2001) Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31(8):2313-8 |
| abstractText | Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the L-tryptophan-kynurenine pathway, which converts an essential amino acid, L-tryptophan, to N-formylkynurenine. It has been speculated that IFN-gamma is a dominant IDO inducer in vivo. The present study used IFN-gamma or TNF-alpha gene-disrupted mice and IFN-gamma antibody-treated mice to demonstrate that lipopolysaccharide (LPS)-induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma. IFN-gamma-independent IDO induction was also demonstrated in vitro with LPS-stimulated monocytic THP-1 cells. These findings clearly indicate that there is an IFN-gamma-independent mechanism of IDO induction in addition to the IFN-gamma-dependent mechanism. |
