| First Author | Schenkel JM | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 5 | Pages | 509-13 |
| PubMed ID | 23542740 | Mgi Jnum | J:196440 |
| Mgi Id | MGI:5488522 | Doi | 10.1038/ni.2568 |
| Citation | Schenkel JM, et al. (2013) Sensing and alarm function of resident memory CD8(+) T cells. Nat Immunol 14(5):509-13 |
| abstractText | CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previously encountered antigens that precipitate innate-like alarm signals and draw circulating memory CD8(+) T cells into the tissue. When memory CD8(+) T cells residing in the female mouse reproductive tract encountered cognate antigen, they expressed interferon-gamma (IFN-gamma), potentiated robust local expression of inflammatory chemokines and induced rapid recruitment of circulating memory CD8(+) T cells. Anamnestic responses in front-line tissues are thus an integrated collaboration between front-line and circulating populations of memory CD8(+) T cells, and vaccines should establish both populations to maximize rapid responses. |
