| First Author | Tishon A | Year | 1995 |
| Journal | Virology | Volume | 212 |
| Issue | 1 | Pages | 244-50 |
| PubMed ID | 7676639 | Mgi Jnum | J:110746 |
| Mgi Id | MGI:3641003 | Doi | 10.1006/viro.1995.1477 |
| Citation | Tishon A, et al. (1995) An essential role for type 1 interferon-gamma in terminating persistent viral infection. Virology 212(1):244-50 |
| abstractText | The mechanism(s) by which infectious material is cleared by the host is an area of intensive study. This is especially so with the realization that persistent viral infection is a cause of chronic disease in humans and presents a major health problem. We have used the murine model of infection with lymphocytic choriomeningitis virus to evaluate immune clearance. Mice with a targeted disruption of the IFN-gamma gene mount effective cytotoxic T lymphocyte (CTL) responses after an acute viral challenge and clear virus. CD4+ T cells are not required but CD8+ T cells are mandatory. In contrast, CTL from mice with targeted disruption of the IFN-gamma gene are unable to clear virus from persistently infected mice. In addition to the requirement for IFN-gamma, CD4+ T cells are essential for maintaining a CD8(+)-mediated cure of persistent viral infection. |
