| First Author | Rijneveld AW | Year | 2002 |
| Journal | J Infect Dis | Volume | 185 |
| Issue | 1 | Pages | 91-7 |
| PubMed ID | 11756986 | Mgi Jnum | J:73620 |
| Mgi Id | MGI:2156102 | Doi | 10.1086/338122 |
| Citation | Rijneveld AW, et al. (2002) The role of interferon-gamma in murine pneumococcal pneumonia. J Infect Dis 185(1):91-7 |
| abstractText | To determine the role of interferon (IFN)-gamma in pneumonia, IFN-gamma receptor-deficient (IFN-gamma R(-/-)) and 129/Sv (wild-type [wt]) mice were inoculated intranasally with Streptococcus pneumoniae. Although mortality did not differ between the groups 48 h after inoculation, IFN-gamma R(-/-) mice had significantly fewer pneumococci in their lungs than the wt mice. Similarly, IFN-gamma(-/-) mice had fewer colony-forming units in lungs than wt mice. The relatively increased resistance of IFN-gamma R(-/-) mice was not related to favorable effects on defense mechanisms known to contribute to antibacterial immunity-that is, the neutrophilic influx was reduced and the cytokine and nitric oxide levels were similar or lower in IFN-gamma R(-/-) mice. In contrast, mice treated with anti-IFN-gamma did not demonstrate a consistently altered bacterial outgrowth, compared with mice treated with a control antibody. These data suggest that endogenous IFN-gamma, despite its protective role in defense against intracellular pathogens, does not serve a protective role during pneumococcal pneumonia. |
