| First Author | Ely KH | Year | 1999 |
| Journal | J Immunol | Volume | 162 |
| Issue | 9 | Pages | 5449-54 |
| PubMed ID | 10228024 | Mgi Jnum | J:111011 |
| Mgi Id | MGI:3652620 | Doi | 10.4049/jimmunol.162.9.5449 |
| Citation | Ely KH, et al. (1999) Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162(9):5449-54 |
| abstractText | The importance of IFN-gamma in regulating the host CD8+ T cell response during microbial infection has not been delineated. Mice deficient for the p40 chain of the IL-12 heterodimer have impaired IFN-gamma production and are susceptible to infection with the intracellular parasite Toxoplasma gondii. The administration of exogenous IFN-gamma to parasite-infected p40-/- mice increases survival and up-regulates the depressed CD8+ T cell response following infection. CD8+ T cells isolated from cytokine-treated p40-/- mice exhibit an increase in both precursor CTL frequency and IFN-gamma production compared with untreated controls. The enhancement of the CD8+ T cell response is independent of CD4+ T cell help. These CD8+ T cells induce protective immunity against a lethal challenge when adoptively transferred into naive p40-/- and IFN-gamma-/- mice. These observations indicate that IFN-gamma can regulate the CD8+ T cell response during T. gondii infection. |
