| First Author | Eisenring M | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 11 | Pages | 1030-8 |
| PubMed ID | 20935648 | Mgi Jnum | J:166535 |
| Mgi Id | MGI:4847989 | Doi | 10.1038/ni.1947 |
| Citation | Eisenring M, et al. (2010) IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11(11):1030-8 |
| abstractText | The potent tumoricidal activity of interleukin 12 (IL-12) is thought to be mediated by the activation and polarization of natural killer (NK) cells and T helper type 1 (T(H)1) cells, respectively. By systematic analysis of the IL-12-induced immune response to subcutaneous melanoma (B16), we found that tumor suppression was mediated independently of T lymphocytes or NK cells. IL-12 initiated local antitumor immunity by stimulating a subset of NKp46(+) lymphoid tissue-inducer (LTi) cells dependent on the transcription factor RORgammat. The presence of these NKp46(+) LTi cells induced upregulation of adhesion molecules in the tumor vasculature and resulted in more leukocyte invasion. Thus, this innate cell type is responsive to IL-12 and is a powerful mediator of tumor suppression. |
