| First Author | Wejksza K | Year | 2013 |
| Journal | J Immunol | Volume | 190 |
| Issue | 6 | Pages | 2575-84 |
| PubMed ID | 23408836 | Mgi Jnum | J:193679 |
| Mgi Id | MGI:5469211 | Doi | 10.4049/jimmunol.1201920 |
| Citation | Wejksza K, et al. (2013) Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor alpha. J Immunol 190(6):2575-84 |
| abstractText | Breast cancer cells facilitate distant metastasis through the induction of immunosuppressive regulatory B cells, designated tBregs. We report in this study that, to do this, breast cancer cells produce metabolites of the 5-lipoxygenase pathway such as leukotriene B to activate the peroxisome proliferator-activated receptor alpha (PPARalpha) in B cells. Inactivation of leukotriene B signaling or genetic deficiency of PPARalpha in B cells blocks the generation of tBregs and thereby abrogates lung metastasis in mice with established breast cancer. Thus, in addition to eliciting fatty acid oxidation and metabolic signals, PPARalpha initiates programs required for differentiation of tBregs. We propose that PPARalpha in B cells and/or tumor 5-lipoxygenase pathways represents new targets for pharmacological control of tBreg-mediated cancer escape. |
