| First Author | Kouskoff V | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 5 | Pages | 811-22 |
| PubMed ID | 8945509 | Mgi Jnum | J:36815 |
| Mgi Id | MGI:84228 | Doi | 10.1016/s0092-8674(00)81989-3 |
| Citation | Kouskoff V, et al. (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22 |
| abstractText | Rheumatoid arthritis (RA) is a chronic joint disease characterized by leukocyte invasion and synoviocyte activation followed by cartilage and bone destruction. Its etiology and pathogenesis are poorly understood. We describe a spontaneous mouse model of this syndrome, generated fortuitously by crossing a T cell receptor (TCR) transgenic line with the NOD strain. All offspring develop a joint disease highly reminiscent of RA in man. The trigger for the murine disorder is chance recognition of a NOD-derived major histocompatibility complex (MHC) class II molecule by the transgenic TCR; progression to arthritis involves CD4+ T, B, and probably myeloid cells. Thus, a joint-specific disease need not arise from response to a joint-specific antigen but can be precipitated by a breakdown in general mechanisms of self-tolerance resulting in systemic self-reactivity. We suggest that human RA develops by an analogous mechanism. |
