| First Author | Talay O | Year | 2012 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 4 | Pages | 396-404 |
| PubMed ID | 22366892 | Mgi Jnum | J:334613 |
| Mgi Id | MGI:7449384 | Doi | 10.1038/ni.2256 |
| Citation | Talay O, et al. (2012) IgE(+) memory B cells and plasma cells generated through a germinal-center pathway. Nat Immunol 13(4):396-404 |
| abstractText | Immunoglobulin E (IgE) antibodies are pathogenic in asthma and allergic diseases, but the in vivo biology of IgE-producing (IgE(+)) cells is poorly understood. A model of the differentiation of IgE(+) B cells proposes that IgE(+) cells develop through a germinal-center IgG1(+) intermediate and that IgE memory resides in the compartment of IgG1(+) memory B cells. Here we have used a reporter mouse expressing green fluorescent protein associated with membrane IgE transcripts (IgE-GFP) to assess in vivo IgE responses. In contrast to the IgG1-centered model of IgE switching and memory, we found that IgE(+) cells developed through a germinal-center IgE(+) intermediate to form IgE(+) memory B cells and plasma cells. Our studies delineate a new model for the in vivo biology of IgE switching and memory. |
