| First Author | Kitamura D | Year | 1992 |
| Journal | Nature | Volume | 356 |
| Issue | 6365 | Pages | 154-6 |
| PubMed ID | 1545868 | Mgi Jnum | J:64298 |
| Mgi Id | MGI:1889067 | Doi | 10.1038/356154a0 |
| Citation | Kitamura D, et al. (1992) Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion [see comments]. Nature 356(6365):154-6 |
| abstractText | Burnet's clonal selection theory suggests that each B lymphocyte is committed to a single antibody specificity. This is achieved by a programme of somatic rearrangements of the gene segments encoding antibody variable (V) regions, in the course of B-cell development. Evidence from immunoglobulin-transgenic mice and immunoglobulin-gene-transfected transformed pre-B cells suggest that the membrane form of the immunoglobulin heavy (H) chain of class mu (microns), expressed from a rearranged H-chain (IgH) locus, may signal allelic exclusion of the homologous IgH locus in the cell and initiation of light (L)-chain gene rearrangement in the Ig kappa loci. We report here that targeted disruption of the membrane exon of the mu chain indeed results in the loss of H-chain allelic exclusion. But, some kappa chain gene rearrangement is still observed in the absence of micron expression. |
