| First Author | Mittrücker HW | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 4 | Pages | 1648-52 |
| PubMed ID | 10657605 | Mgi Jnum | J:60395 |
| Mgi Id | MGI:1353241 | Doi | 10.4049/jimmunol.164.4.1648 |
| Citation | Mittrucker HW, et al. (2000) Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection. J Immunol 164(4):1648-52 |
| abstractText | Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Igmu-/- mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Igmu+/+ mice, LD50 values in Igmu-/- mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Igmu-/- mice cleared attenuated aroA- S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice. |
