| First Author | Klarquist J | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 8 | Pages | 109591 |
| PubMed ID | 34433030 | Mgi Jnum | J:314212 |
| Mgi Id | MGI:6765714 | Doi | 10.1016/j.celrep.2021.109591 |
| Citation | Klarquist J, et al. (2021) B cells promote CD8 T cell primary and memory responses to subunit vaccines. Cell Rep 36(8):109591 |
| abstractText | The relationship between B cells and CD4 T cells has been carefully studied, revealing a collaborative effort in which B cells promote the activation, differentiation, and expansion of CD4 T cells while the so-called "helper" cells provide signals to B cells, influencing their class switching and fate. Interactions between B cells and CD8 T cells are not as well studied, although CD8 T cells exhibit an accelerated contraction after certain infections in B-cell-deficient mice. Here, we find that B cells significantly enhance primary CD8 T cell responses after vaccination. Moreover, memory CD8 numbers and function are impaired in B-cell-deficient animals, leading to increased susceptibility to bacterial challenge. We also show that interleukin-27 production by B cells contributes to their impact on primary, but not memory, CD8 responses. Better understanding of the interactions between CD8 T cells and B cells may aid in the design of more effective future vaccine strategies. |
