| First Author | Nanton MR | Year | 2012 |
| Journal | J Immunol | Volume | 189 |
| Issue | 12 | Pages | 5503-7 |
| PubMed ID | 23150714 | Mgi Jnum | J:190860 |
| Mgi Id | MGI:5449802 | Doi | 10.4049/jimmunol.1201413 |
| Citation | Nanton MR, et al. (2012) Cutting Edge: B Cells Are Essential for Protective Immunity against Salmonella Independent of Antibody Secretion. J Immunol 189(12):5503-7 |
| abstractText | Typhoid fever and nontyphoidal bacteremia caused by Salmonella remain critical human health problems. B cells are required for protective immunity to Salmonella, but the mechanism of protection remains unclear. In this study, we immunized wild-type, B cell-deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella and examined protection against secondary infection. As expected, wild-type mice were protected and B cell-deficient mice succumbed to secondary infection. Interestingly, mice with B cells but lacking secreted Ab or class-switched Ab had little deficiency in resistance to Salmonella infection. The susceptibility of B cell-deficient mice correlated with marked reductions in CD4 T cell IFN-gamma production after secondary infection. Taken together, these data suggest that the primary role of B cells in acquired immunity to Salmonella is via the development of protective T cell immunity. |
