| First Author | Wolf SD | Year | 1996 |
| Journal | J Exp Med | Volume | 184 |
| Issue | 6 | Pages | 2271-8 |
| PubMed ID | 8976182 | Mgi Jnum | J:38002 |
| Mgi Id | MGI:85395 | Doi | 10.1084/jem.184.6.2271 |
| Citation | Wolf SD, et al. (1996) Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 184(6):2271-8 |
| abstractText | Experimental autoimmune encephalomyelitis (EAE) is an animal model for autoimmune central nervous system disease mediated by CD4 T cells. To examine the role of B cells in the induction of EAE, we used B10.PL (I-A(u)) mice rendered deficient in B cells by deletion of their mu chain transmembrane region (B10.PL mu MT). By immunizing B10.PL and B10.PL mu MT mice with the NH-terminal myelin basic protein encephalitogenic peptide Ac1-11, we observed no difference in the onset or severity of disease in the absence of mature B cells. There was, however, a greater variation in disease onset, severity, and especially of recovery in the B cell-deficient mice compared to controls. B10.PL mu MT mice rarely returned to normal in the absence of B cells. Taken together, our data suggest that B cells do not play a role in the activation of encephalitogenic T cells, but may contribute to the immune modulation of acute EAE. The mechanisms to explain these effects are discussed. |
