| First Author | Rong HM | Year | 2019 |
| Journal | Am J Physiol Lung Cell Mol Physiol | Volume | 316 |
| Issue | 1 | Pages | L291-L301 |
| PubMed ID | 30284926 | Mgi Jnum | J:269605 |
| Mgi Id | MGI:6273727 | Doi | 10.1152/ajplung.00210.2018 |
| Citation | Rong HM, et al. (2019) IL-10-producing B cells regulate Th1/Th17-cell immune responses in Pneumocystis pneumonia. Am J Physiol Lung Cell Mol Physiol 316(1):L291-L301 |
| abstractText | Pneumocystis pneumonia (PCP) is a common opportunistic infectious disease that is prevalent in immunosuppressed hosts. Accumulating evidence shows that B cells play an important role in infectious diseases. In the present study, the immune regulatory role of mature B cells in host defense to Pneumocystis was evaluated. Pneumocystis infection resulted in a decrease in B cells in patients and mice, and the Pneumocystis burden in B cell-deficient mice also progressively increased from weeks 1 to 7 after infection. The clearance of Pneumocystis was delayed in B cell-activating factor receptor (BAFF-R)-deficient mice (BAFF-R(-/-) mice), which had few B cells and Pneumocystis-specific IgG and IgM antibodies, compared with clearance in wild-type (WT) mice. There were fewer effector CD4(+) T cells and higher percentages of T helper (Th)1/Th17 cells in BAFF-R(-/-) mice than in WT mice. Adoptive transfer of naive B cells, mRNA sequencing, and IL-1beta neutralization experiments indicated that IL-1beta is a likely determinant of the IL-10-producing B cell-mediated suppression of Th1/Th17-cell immune responses in BAFF-R(-/-) PCP mice. Our data indicated that B cells play a vital role in the regulation of Th cells in response to Pneumocystis infection. |
