| First Author | Laouar A | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 7 | Pages | 698-706 |
| PubMed ID | 15937486 | Mgi Jnum | J:99148 |
| Mgi Id | MGI:3581345 | Doi | 10.1038/ni1212 |
| Citation | Laouar A, et al. (2005) CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat Immunol 6(7):698-706 |
| abstractText | One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection. |
