| First Author | Coro ES | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 7 | Pages | 4343-51 |
| PubMed ID | 16547272 | Mgi Jnum | J:129867 |
| Mgi Id | MGI:3770331 | Doi | 10.4049/jimmunol.176.7.4343 |
| Citation | Coro ES, et al. (2006) Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection. J Immunol 176(7):4343-51 |
| abstractText | Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses. |
