| First Author | Giroux M | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 7 | Pages | 4492-502 |
| PubMed ID | 17878345 | Mgi Jnum | J:152353 |
| Mgi Id | MGI:4358043 | Doi | 10.4049/jimmunol.179.7.4492 |
| Citation | Giroux M, et al. (2007) T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol 179(7):4492-502 |
| abstractText | The spleen contains numerous NK cells whose differentiation profile is characterized by a preponderance of mature elements located mainly in the red pulp. In contrast, lymph nodes (LNs) contain few NK cells and they are sited mostly in T cell zones and skewed toward immature developmental stages. We show that, in mice, naturally occurring CD4+ Foxp3+ regulatory T (Treg) cells are both necessary and sufficient to repress accumulation of NK cells in resting LNs. Moreover, we present evidence that Treg cells hamper generation of mature NK cells through short-range interactions with NK precursors. In turn, mature NK cells specifically regulate the amount of CD8alpha+ phenotypically immature dendritic cells present in LN T cell zones. We propose that the dominant influence of Treg cells on NK cell precursors and CD8alpha+ immature dendritic cells explains why 'quiescent' LNs in the absence of infection function as privileged sites for induction and maintenance of tolerance to peripheral Ags. |
