| First Author | Halim TYF | Year | 2018 |
| Journal | Immunity | Volume | 48 |
| Issue | 6 | Pages | 1195-1207.e6 |
| PubMed ID | 29907525 | Mgi Jnum | J:267611 |
| Mgi Id | MGI:6269165 | Doi | 10.1016/j.immuni.2018.05.003 |
| Citation | Halim TYF, et al. (2018) Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells. Immunity 48(6):1195-1207.e6 |
| abstractText | The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate lymphoid cells (ILC2s) provided tissue-restricted T cell co-stimulation that was indispensable for Th2 and regulatory T (Treg) cell responses in the lung and adipose tissue. Interleukin (IL)-33 administration resulted in organ-specific surface expression of OX40L on ILC2s and the concomitant expansion of Th2 and Treg cells, which was abolished upon deletion of OX40L on ILC2s (Il7ra(Cre/+)Tnfsf4(fl/fl) mice). Moreover, Il7ra(Cre/+)Tnfsf4(fl/fl) mice failed to mount effective Th2 and Treg cell responses and corresponding adaptive type 2 pulmonary inflammation arising from Nippostrongylus brasiliensis infection or allergen exposure. Thus, the increased expression of OX40L in response to IL-33 acts as a licensing signal in the orchestration of tissue-specific adaptive type 2 immunity, without which this response fails to establish. |
