| First Author | Ma A | Year | 1995 |
| Journal | J Exp Med | Volume | 182 |
| Issue | 5 | Pages | 1567-72 |
| PubMed ID | 7595226 | Mgi Jnum | J:29999 |
| Mgi Id | MGI:77521 | Doi | 10.1084/jem.182.5.1567 |
| Citation | Ma A, et al. (1995) T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med 182(5):1567-72 |
| abstractText | Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH-deficient mice (JH-/-, lacking B cells). IL-2-/-, RAG-2-/- double-mutant mice are disease free, while IL-2-/-, JH-/- double-mutant mice succumb to bowel disease at the same rate as IL-2-/- littermates. IL-2-/-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells. |
