| First Author | Baba T | Year | 2020 |
| Journal | Elife | Volume | 9 |
| PubMed ID | 32366355 | Mgi Jnum | J:291155 |
| Mgi Id | MGI:6444978 | Doi | 10.7554/eLife.54257 |
| Citation | Baba T, et al. (2020) Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration. Elife 9:e54257 |
| abstractText | Age-associated sterile inflammation can cause dysregulated choroidal neovascularization (CNV) as age-related macular degeneration (AMD). Intraocular fluid screening of 234 AMD patients identified high levels of IL-4. The purpose of this study was to determine the functional role of IL-4 in CNV formation using murine CNV model. Our results indicate that the IL-4/IL-4 receptors (IL4Rs) controlled tube formation and global proangiogenic responses of bone marrow cells. CCR2(+) bone marrow cells were recruited to form very early CNV lesions. IL-4 rapidly induces CCL2, which enhances recruitment of CCR2(+) bone marrow cells. This in vivo communication, like quorum-sensing, was followed by the induction of IL-4 by the bone marrow cells during the formation of mature CNVs. For CNV development, IL-4 in bone marrow cells are critically required, and IL-4 directly promotes CNV formation mainly by IL-4R. The IL-4/IL-4Ralpha axis contributes to pathological angiogenesis through communications with bone marrow cells leading to retinal degeneration. |
