| First Author | Li H | Year | 2021 |
| Journal | Biochim Biophys Acta Mol Cell Res | Volume | 1868 |
| Issue | 10 | Pages | 119080 |
| PubMed ID | 34174290 | Mgi Jnum | J:307964 |
| Mgi Id | MGI:6727211 | Doi | 10.1016/j.bbamcr.2021.119080 |
| Citation | Li H, et al. (2021) Peripheral IL-6/STAT3 signaling promotes beiging of white fat. Biochim Biophys Acta Mol Cell Res 1868(10):119080 |
| abstractText | Interleukin-6 (IL-6) can reportedly centrally affect the thermogenesis of brown fat. However, whether the peripheral IL-6 signaling regulates beiging of white fat remains largely unknown. In vitro experiments indicated IL-6-KO-derived white adipocytes exhibited lower thermogenic gene expression compared to the WT, associating with reduced phosphorylation of STAT3 at Tyr705. Mechanistically, exogenous IL-6 application increased the p-STAT3(Tyr705) level, thus the phosphorylated STAT3 bound to the promoter regions, and enhanced the transcription of Ppargamma and Ucp1. The protein interaction of PGC-1alpha with PPARgamma was increased by IL-6, which also contributed to stimulate Ucp1 expression. In vivo experiments demonstrated that IL-6 KO decreased the beiging potential of white fat with suppressed STAT3 Tyr705 phosphorylation. Accordingly, IL-6-KO mature mice were associated with disrupted glucose homeostasis and accelerated hepatic steatosis. Collectively, we identified a novel function of peripheral IL-6/STAT3 signaling which is essential for beiging of white fat, such ensuring fat and glucose homeostasis. |
