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Publication : Impairment of recognition memory in interleukin-6 knock-out mice.

First Author  Hryniewicz A Year  2007
Journal  Eur J Pharmacol Volume  577
Issue  1-3 Pages  219-20
PubMed ID  17920057 Mgi Jnum  J:139627
Mgi Id  MGI:3808980 Doi  10.1016/j.ejphar.2007.08.046
Citation  Hryniewicz A, et al. (2007) Impairment of recognition memory in interleukin-6 knock-out mice. Eur J Pharmacol 577(1-3):219-20
abstractText  We have used transgenic male mice not expressing interleukin-6 (IL-6) [C57BL/6J(IL-6/-tm Kopf)] in object recognition test to assess the role of endogenous IL-6 in recognition memory. Wild-type controls showed better memory than IL-6 knock-out mice. Results of our experiment suggest that endogenous IL-6 may play an important role in the process of recognition memory in mice.
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