| First Author | Molotkov A | Year | 1998 |
| Journal | Cancer Lett | Volume | 132 |
| Issue | 1-2 | Pages | 187-92 |
| PubMed ID | 10397473 | Mgi Jnum | J:51769 |
| Mgi Id | MGI:1326842 | Doi | 10.1016/s0304-3835(98)00182-7 |
| Citation | Molotkov A, et al. (1998) Tumor growth and food intake in interleukin-6 gene knock-out mice. Cancer Lett 132(1-2):187-92 |
| abstractText | Interleukin (IL)-6 has potential antitumor activity and at the same time is responsible for tumor-derived cachexia. Using IL-6 gene knock-out (GKO) mice, we investigated the effect of IL-6 deficiency on the survival time, tumor growth and daily food intake of mice inoculated with Ehrlich ascites carcinoma. IL-6 GKO mice gained weight due to tumor growth more rapidly than the wild-type mice. The daily food intake of wild-type mice declined on day 2 after tumor inoculation and was only 37% on day 8. In contrast, the daily food intake of IL-6 GKO mice was constant for the first 7 days after tumor inoculation. Although wild-type mice suffered from cachexia, their survival time was significantly longer than that of IL-6 GKO mice. We propose that both IL-6 secretion and cancer cachexia syndrome may be involved in the defense mechanism against tumor progression. |
