| First Author | Kashem SW | Year | 2015 |
| Journal | Immunity | Volume | 42 |
| Issue | 2 | Pages | 356-366 |
| PubMed ID | 25680275 | Mgi Jnum | J:223828 |
| Mgi Id | MGI:5660452 | Doi | 10.1016/j.immuni.2015.01.008 |
| Citation | Kashem SW, et al. (2015) Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation. Immunity 42(2):356-66 |
| abstractText | Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and systemic infections. Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C. albicans. Systemic immunity is considered T cell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C. albicans. We found that only yeast induced Th17 cell responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by Langerhans cells. Filamentous forms induced Th1 without Th17 cell responses due to the absence of Dectin-1 ligation. Notably, Th17 cell responses provided protection against cutaneous infection while Th1 cell responses provided protection against systemic infection. Thus, C. albicans morphology drives distinct T helper cell responses that provide tissue-specific protection. These findings provide insight into compartmentalization of Th cell responses and C. albicans pathogenesis and have critical implications for vaccine strategies. |
