| First Author | Porter BO | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 1 | Pages | 262-9 |
| PubMed ID | 11123301 | Mgi Jnum | J:66400 |
| Mgi Id | MGI:1928421 | Doi | 10.4049/jimmunol.166.1.262 |
| Citation | Porter BO, et al. (2001) Control of T cell development In vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail. J Immunol 166(1):262-9 |
| abstractText | IL-7/IL-7R signaling functions in both growth and differentiation during T cell development. In this study, we examined the extent these activities were controlled by signaling associated with distinct IL-7Ralpha cytoplasmic domains by transgenic expression of wild-type or cytoplasmic deletion mutants of IL-7Ralpha in the thymi of IL-7Ralpha(-/-) mice. We show an essential requirement for the tyrosine-containing carboxyl-terminal T domain in restoring thymic cellularity, pro-/pre-T cell progression, and survival. In contrast, the functional differentiation of TCR alphass cells and the development of TCR gammadelta cells are partially independent of the T domain. Thus, separate cytoplasmic domains of the IL-7Ralpha chain differentially control distinct functions during T cell development, whereas normal IL-7R-dependent thymic development requires the integrated activity of all these domains. |
