| First Author | Londoño D | Year | 2008 |
| Journal | Infect Immun | Volume | 76 |
| Issue | 12 | Pages | 5508-13 |
| PubMed ID | 18794280 | Mgi Jnum | J:142597 |
| Mgi Id | MGI:3821808 | Doi | 10.1128/IAI.00587-08 |
| Citation | Londono D, et al. (2008) Relapsing fever borreliosis in interleukin-10-deficient mice. Infect Immun 76(12):5508-13 |
| abstractText | Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10) in the circulation. We investigated the possibility that IL-10 plays an important protective role in this infection using wild-type and IL-10-deficient mice inoculated with virulent serotype 2 of the RF spirochete Borrelia turicatae. During peak bacteremia there was increased systemic production of IL-10 that quickly resolved in the postpeak period; in contrast, IL-6 and CXCL13 production increased during the peak but remained elevated during postpeak bacteremia. IL-10 deficiency resulted in lower bacteremia, increased specific antibody production, higher production of CXCL13 and IL-6, and thrombotic and hemorrhagic complications affecting multiple organs with secondary tissue injury. Our results revealed that production of IL-10 is highly regulated during RF and plays an important protective role in the prevention of hemorrhagic and thrombotic complications at the cost of reduced pathogen control. |
