| First Author | Maynard CL | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 9 | Pages | 931-41 |
| PubMed ID | 17694059 | Mgi Jnum | J:124255 |
| Mgi Id | MGI:3721180 | Doi | 10.1038/ni1504 |
| Citation | Maynard CL, et al. (2007) Regulatory T cells expressing interleukin 10 develop from Foxp3(+) and Foxp3(-) precursor cells in the absence of interleukin 10. Nat Immunol 8(9):931-41 |
| abstractText | CD4(+) regulatory T cells (T(reg) cells) that produce interleukin 10 (IL-10) are important contributors to immune homeostasis. We generated mice with a 'dual-reporter' system of the genes encoding IL-10 and the transcription factor Foxp3 to track T(reg) subsets based on coordinate or differential expression of these genes. Secondary lymphoid tissues, lung and liver had enrichment of Foxp3(+)IL-10(-) T(reg) cells, whereas the large and small intestine had enrichment of Foxp3(+)IL-10(+) and Foxp3(-)IL-10(+) T(reg) cells, respectively. Although negative for Il10 expression, both Foxp3(+) and Foxp3(-) CD4(+) thymic precursor cells gave rise to peripheral IL-10(+) T(reg) cells, with only Foxp3(-) precursor cells giving rise to all T(reg) subsets. Each T(reg) subset developed in IL-10-deficient mice, but this was blocked by treatment with antibody to transforming growth factor-beta. Thus, Foxp3(+) and Foxp3(-) precursor cells give rise to peripheral IL-10-expressing T(reg) cells by a mechanism dependent on transforming growth factor-beta and independent of IL-10. |
