| First Author | Balasa B | Year | 2000 |
| Journal | Cell Immunol | Volume | 202 |
| Issue | 2 | Pages | 97-102 |
| PubMed ID | 10896769 | Mgi Jnum | J:114170 |
| Mgi Id | MGI:3688457 | Doi | 10.1006/cimm.2000.1658 |
| Citation | Balasa B, et al. (2000) IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse. Cell Immunol 202(2):97-102 |
| abstractText | IL-10 exterts profound immunostimulatory and immunoinhibitory effects. To explore the role of IL-10 in autoimmune diabetes of nonobese diabetic (NOD) mice, we generated IL-10-deficient NOD mice. In contrast to our previous results with neutralizing antibodies to IL-10, IL-10-deficient NOD mice developed insulitis and their splenocytes readily responded to islet antigen glutamic acid decarboxylase 65. IL-10-deficient NOD mice did not develop accelerated spontaneous diabetes. On the other hand, IL-10-deficient NOD mice developed accelerated disease following cyclophosphamide (CYP) injection. These findings demonstrate that IL-10 is dispensable for autoimmune diabetes. IL-10's absence fails to accelerate endogenous diabetes but potentiates CYP-induced diabetes. |
