| First Author | Tanoue T | Year | 2019 |
| Journal | Nature | Volume | 565 |
| Issue | 7741 | Pages | 600-605 |
| PubMed ID | 30675064 | Mgi Jnum | J:301468 |
| Mgi Id | MGI:6276715 | Doi | 10.1038/s41586-019-0878-z |
| Citation | Tanoue T, et al. (2019) A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature 565(7741):600-605 |
| abstractText | There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-gamma-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103(+) dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics. |
