| First Author | Gonnella PA | Year | 2004 |
| Journal | J Autoimmun | Volume | 23 |
| Issue | 3 | Pages | 193-200 |
| PubMed ID | 15501390 | Mgi Jnum | J:93230 |
| Mgi Id | MGI:3056257 | Doi | 10.1016/j.jaut.2004.08.001 |
| Citation | Gonnella PA, et al. (2004) Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. J Autoimmun 23(3):193-200 |
| abstractText | IL-10 has been shown to be an important anti-inflammatory mediator that has both down-regulatory and immunomodulatory effects. Utilizing IL-10(-/-) mice we demonstrate the induction of low dose oral tolerance characterized by the up-regulation of TGF-beta and IL-4 and the suppression of Ag specific proliferation with little suppression of INF-gamma. More severe EAE was found in IL-10(-/-) mice than in wild type controls, however, feeding resulted in amelioration of disease severity in both groups. Orally tolerized IL-10(-/-) mice had greater disease severity compared to orally tolerized wild type mice. IL-4 was present in the GALT of IL-10(-/-) mice and up-regulation of TGF-beta was detected in the lamina propria of fed mice. These results demonstrate that IL-10 is not required for the induction of low dose oral tolerance but is required for the regulation of INF-gamma which affects severity of disease in tolerized mice. |
