| First Author | Gungabeesoon J | Year | 2023 |
| Journal | Cell | Volume | 186 |
| Issue | 7 | Pages | 1448-1464.e20 |
| PubMed ID | 37001504 | Mgi Jnum | J:334891 |
| Mgi Id | MGI:7463782 | Doi | 10.1016/j.cell.2023.02.032 |
| Citation | Gungabeesoon J, et al. (2023) A neutrophil response linked to tumor control in immunotherapy. Cell 186(7):1448-1464.e20 |
| abstractText | Neutrophils accumulate in solid tumors, and their abundance correlates with poor prognosis. Neutrophils are not homogeneous, however, and could play different roles in cancer therapy. Here, we investigate the role of neutrophils in immunotherapy, leading to tumor control. We show that successful therapies acutely expanded tumor neutrophil numbers. This expansion could be attributed to a Sell(hi) state rather than to other neutrophils that accelerate tumor progression. Therapy-elicited neutrophils acquired an interferon gene signature, also seen in human patients, and appeared essential for successful therapy, as loss of the interferon-responsive transcription factor IRF1 in neutrophils led to failure of immunotherapy. The neutrophil response depended on key components of anti-tumor immunity, including BATF3-dependent DCs, IL-12, and IFNgamma. In addition, we found that a therapy-elicited systemic neutrophil response positively correlated with disease outcome in lung cancer patients. Thus, we establish a crucial role of a neutrophil state in mediating effective cancer therapy. |
