| First Author | Feng C | Year | 1999 |
| Journal | Int Immunol | Volume | 11 |
| Issue | 8 | Pages | 1185-94 |
| PubMed ID | 10421776 | Mgi Jnum | J:56761 |
| Mgi Id | MGI:1342391 | Doi | 10.1093/intimm/11.8.1185 |
| Citation | Feng C, et al. (1999) An alternate pathway for type 1 T cell differentiation. Int Immunol 11(8):1185-94 |
| abstractText | IFN-regulatory factor-1 (IRF-1) gene-disrupted mice are defective in IL-12 and IL-18 gene expression at the transcriptional and post-translational level respectively. The mutant mouse mounts a type 2 T cell response upon bacterial infection because of the impaired induction of the IL-12 p40 gene and IFN-gamma-producing type 1 T cells are not induced. We showed here, however, that different pathogens activate a novel pathway for inducing IFN-gamma-producing type 1 T cells even in an IRF-1-deficient mouse. This pathway is independent of IL-12 and IL-18, and is mediated by a distinct function of macrophage lineage cells. Macrophages of the mutant mice fail to activate the IL-12-dependent pathway, but they function in the IL-12-independent pathway in Plasmodium-infected mice. This leads to the hypothesis that the IL-12-independent novel pathway for inducing IFN-gamma-producing T cells is distinct from the classical type 1/type 2 T cell subset differentiation pathway. |
