| First Author | Chapman RS | Year | 2000 |
| Journal | Oncogene | Volume | 19 |
| Issue | 54 | Pages | 6386-91 |
| PubMed ID | 11175354 | Mgi Jnum | J:123430 |
| Mgi Id | MGI:3718294 | Doi | 10.1038/sj.onc.1204016 |
| Citation | Chapman RS, et al. (2000) A novel role for IRF-1 as a suppressor of apoptosis. Oncogene 19(54):6386-91 |
| abstractText | The tumour suppressor IRF-1 is a transcription factor involved in the induction of apoptosis in several in vitro systems. Post-lactational involution of the mammary gland is characterized by extensive apoptosis of the epithelial cells. We have previously shown that signal transducer and activator of transcription (Stat) 3 drives apoptosis and involution in the mouse mammary gland. Since one of the downstream targets of the Stat signalling pathway is IRF-1, we have used IRF-1 knockout mice to address the potential role of this transcription factor in involution. Surprisingly, in the absence of IRF-1 significantly higher numbers of apoptotic cells were found in involuting glands at 48 h compared to control glands. In addition, the alveolar structure in IRF-1 null mammary glands had collapsed whereas in control glands the alveoli remained intact and distended. However, by 72 h control and null glands were morphologically similar suggesting that IRF-1 suppresses apoptosis only during the early, reversible, stage of involution. This suggests a survival role for IRF-1 in mammary epithelia and demonstrates a novel role for IRF-1 in vivo--suppression of premature epithelial apoptosis during mammary gland involution. |
