| First Author | Daley JM | Year | 2005 |
| Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 288 |
| Issue | 2 | Pages | R409-12 |
| PubMed ID | 15458967 | Mgi Jnum | J:104758 |
| Mgi Id | MGI:3612752 | Doi | 10.1152/ajpregu.00322.2004 |
| Citation | Daley JM, et al. (2005) Transcriptional regulation of TNF-alpha production in neutropenia. Am J Physiol Regul Integr Comp Physiol 288(2):R409-12 |
| abstractText | Neutropenia has been shown to markedly increase plasma TNF-alpha concentration after LPS injection and to enhance LPS-induced mortality. Experiments reported here demonstrate that the 15-fold higher plasma TNF-alpha concentration elicited by LPS in neutropenic vs. nonneutropenic unanesthetized mice correlated with increased hepatic and splenic, but not pulmonary, TNF-alpha mRNA. Core 2 beta-1,6-N-acetylglucosaminyltransferase-null and CD18-deficient mice also exhibited exaggerated plasma TNF-alpha responses to LPS injection. Findings suggest that extravasated neutrophils inhibit systemic TNF-alpha production and that they do so through organ-selective mechanisms involving CD18 integrin and selectin binding. |
