| First Author | Groves T | Year | 1996 |
| Journal | Immunity | Volume | 5 |
| Issue | 5 | Pages | 417-28 |
| PubMed ID | 8934569 | Mgi Jnum | J:37062 |
| Mgi Id | MGI:84468 | Doi | 10.1016/s1074-7613(00)80498-7 |
| Citation | Groves T, et al. (1996) Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5(5):417-28 |
| abstractText | Lck, a Src family tyrosine kinase, transduces signals important for the development of alpha beta and gamma delta T cells. However, T cell development is only partially compromised in Lck-deficient mice, suggesting that other kinases may also transduce pre-TCR or TCR signals. One candidate is Fyn, a Src kinase coexpressed with Lck in immature and mature T cells. Here we show that T cell development is completely compromised in lck(-/- )fyn(-/-) mice. In addition, we demonstrate that expression of a gain-of-function mutant fyn(T) transgene completely restores production of immature CD4/CD8 double positive thymocytes and gamma delta T cells and improves the representation of CD4 or CD8 single positive thymocytes. These observations reveal that Fyn can subserve some Lck-like functions in T cell development. |
