| First Author | Wiede F | Year | 2017 |
| Journal | J Exp Med | Volume | 214 |
| Issue | 9 | Pages | 2733-2758 |
| PubMed ID | 28798028 | Mgi Jnum | J:244288 |
| Mgi Id | MGI:5913067 | Doi | 10.1084/jem.20161903 |
| Citation | Wiede F, et al. (2017) PTPN2 regulates T cell lineage commitment and alphabeta versus gammadelta specification. J Exp Med 214(9):2733-2758 |
| abstractText | In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted alphabeta T cell receptor (TCR) T cells and non-MHC-restricted gammadelta TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into alphabeta TCR versus gammadelta TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate alphabeta TCR versus gammadelta TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into alphabeta TCR or gammadelta TCR T cells. |
