| First Author | van Es T | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 388 |
| Issue | 2 | Pages | 261-5 |
| PubMed ID | 19660432 | Mgi Jnum | J:152718 |
| Mgi Id | MGI:4359561 | Doi | 10.1016/j.bbrc.2009.07.152 |
| Citation | van Es T, et al. (2009) Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. Biochem Biophys Res Commun 388(2):261-5 |
| abstractText | Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant changes in collagen content and neutrophil counts, but a reduction in mast cell number and an increase in macrophage number. In addition, we observed a decrease in anti-oxLDL antibodies of the IgG class upon IL-17R BMT, while introduction of IL-17R deficient bone marrow resulted in a reduced IL-6 production and an increased IL-10 production. In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis. |
