| First Author | Krishack PA | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 16 | Pages | 2650-60 |
| PubMed ID | 27339627 | Mgi Jnum | J:235225 |
| Mgi Id | MGI:5795785 | Doi | 10.1002/1873-3468.12269 |
| Citation | Krishack PA, et al. (2016) Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice. FEBS Lett 590(16):2650-60 |
| abstractText | We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice. |
