| First Author | Wang Y | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 6100 | PubMed ID | 25600442 |
| Mgi Jnum | J:219720 | Mgi Id | MGI:5629617 |
| Doi | 10.1038/ncomms7100 | Citation | Wang Y, et al. (2015) Vaginal type-II mucosa is an inductive site for primary CD8(+) T-cell mucosal immunity. Nat Commun 6:6100 |
| abstractText | The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naive T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8(+) T-cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naive CD8(+) T cells and the local expansion of antigen-specific CD8(+) T cells, thereby demonstrating a different paradigm for primary mucosal T-cell immune induction. |
