| First Author | Doi T | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 425 |
| Issue | 4 | Pages | 918-23 |
| PubMed ID | 22906740 | Mgi Jnum | J:188131 |
| Mgi Id | MGI:5439217 | Doi | 10.1016/j.bbrc.2012.08.010 |
| Citation | Doi T, et al. (2012) IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine. Biochem Biophys Res Commun 425(4):918-23 |
| abstractText | To maintain immune homeostasis in the intestine, the intestinal immune system has evolved several tolerogenic mechanisms toward intestinal microflora and food antigens. Although programmed cell death-1 (PD-1) protein has been implicated in immunological tolerance in the intestine and gut-associated lymphoid tissues (GALTs), distribution of its ligands PD-L1 and PD-L2 in the small intestine lamina propria (LP) are unknown. We investigated PD-L1 expression in intestinal LP and found that IgA plasma cells (PCs) were major PD-L1 expressing cells. PD-L1 expression levels on IgA PCs were higher than that on IgG PCs in peripheral lymphoid tissues. IgA PCs expressed antigen-presenting molecule MHC class II and co-stimulatory molecules CD80, CD86, and PD-L2. IgA PCs isolated from intestinal LP exhibited antigen presentation activity, and in the presence of TGF-beta induced FoxP3(+) regulatory T cells, but not IFN-gamma(+) Th1 cells, from naive T cells. Thus, IgA PCs in the intestine may be involved in an immune regulatory role in the intestinal immune system. |
