| First Author | Kang HS | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 6 | Pages | 576-82 |
| PubMed ID | 12006975 | Mgi Jnum | J:76773 |
| Mgi Id | MGI:2180261 | Doi | 10.1038/ni795 |
| Citation | Kang HS, et al. (2002) Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat Immunol 3(6):576-82 |
| abstractText | Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) are thought to be essential for immunoglobulin A (IgA) production. We found that the severe IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. The number of IgA precursors from LT(-/-) mice was not reduced, and they were able to migrate into the lamina propria (LP) of wild-type mice but not of LTbetaR(-/-) mice. Consistently, lymphoid tissue chemokines and adhesion molecules were reduced within the LP of LTalpha(-/-) and LTbetaR(-/-) mice. IgA deficiency in LTalpha(-/-) mice was reversed by the transplantation of a segment of RAG-1 (recombination-activating gene 1) deficient intestine, which confirmed the dispensability of the MLNs and PPs and the sufficiency of the LT-mediated gut microenvironment for IgA production. |
