| First Author | Cai Z | Year | 2002 |
| Journal | J Peripher Nerv Syst | Volume | 7 |
| Issue | 3 | Pages | 181-9 |
| PubMed ID | 12365566 | Mgi Jnum | J:103883 |
| Mgi Id | MGI:3610830 | Doi | 10.1046/j.1529-8027.2002.02023.x |
| Citation | Cai Z, et al. (2002) Tomacula in MAG-deficient mice. J Peripher Nerv Syst 7(3):181-9 |
| abstractText | The pathogenesis of tomacula in mice with a null mutation of the myelin-associated glycoprotein (MAG) gene is not well understood. This study, using a novel teased nerve fiber technique, demonstrates that tomacula in MAG-deficient mice are formed by redundant myelin infoldings and outfoldings in the paranodal regions as early as 4 weeks after birth and increase in size and frequency with age. Although tomacula show degenerative changes with increasing age, there was no significant evidence of demyelination/remyelination. Longitudinal sections of normal teased nerve fibers show early redundant myelin foldings in externally normal paranodal regions. These data and the absence of internodal tomacula support a role for MAG in the maintenance of myelin at the paranodal regions. |
